Related Products of 1353100-91-0,Some common heterocyclic compound, 1353100-91-0, name is Ethyl 3-bromo-1H-pyrazole-4-carboxylate, molecular formula is C6H7BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0500] to a solution of NAH (1.64 g, 41.09 mmol, 60% purity) in THF (80 ml) at 0 C was added a solution of compound 30b (6 g, 27.39 mmol) in THF (20 ml). After addition, the mixture was warmed up to 25 C and stirred for 2 hrs. Then the solution was cooled to 0 C and a solution of sem-c1 (5.34 ml, 30.13 mmol) in THF (100 ml) was added at 0 C. The mixture was then warmed up to 25 C and stirred for 12 hrs. The reaction was quenched with H2O (100 ml) dropwise. The mixture was extracted with EtOAc (100 ml x 2). The organics were collected and concentrated. The residue was purified by column (petroleum ether: ethyl acetate = 10: 1) to afford compound 30c (3 g, yield: 31.14%) as yellow oil.
The synthetic route of 1353100-91-0 has been constantly updated, and we look forward to future research findings.