Adding a certain compound to certain chemical reactions, such as: 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3994-50-1, Recommanded Product: 1-Methyl-4-nitro-1H-pyrazole
To a N2 flushed pressure vial was added (S)-tert-butyl (1-(4-chloropyridin-2-yl)but-3-en-1-yl)carbamate, prepared as described in Intermediate 23, (3.0 g, 10.61mmol), 1 -methyl-4-nitro- 1H-pyrazole (1 .348 g, 10.61 mmol), di(adamant- 1 -yl)(butyl) phosphine (1.141 g, 3.18 mmol), PvOH (0.369 ml, 3.18 mmol), K2C03 (4.40 g, 31.8 mmol) and DMF (21 mL). The reaction mixture was purged with N2 for 5 mm and Pd(OAc)2 (0.476 g, 2.122 mmol) was added. The reaction mixture was purged with N2.The vial was sealed and heated at 120 C for 4 h. The reaction mixture was cooled to rt and partitioned between 10% aqueous LiC1 (15 mL) and EtOAc (30 mL). The aqueous layer was extracted with EtOAc (2 x 20 mL) and the combined organic layers were washed with brine (15 mL), dried over MgSO4, filtered and concentrated. The crude product was then purified using normal phase chromatography to yield (S)-tert-butyl (1-(4-( 1 -methyl-4-nitro- 1H-pyrazol-5 -yl)pyridin-2-yl)but-3 -en-i -yl)carbamate (1.2 g, 29% yield) as a brown oil. MS(ESI) m/z: 374.4 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.