Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O
Example 15 4-((1,5-Dimethyl-1H-pyrazol-4-yl)methylene)-2-(2-thienyl)-5(4H)-oxazolone To a screw-capped test tube, N-(2-thienylcarbonyl)glycine (56 mg, 0.3 mmol), 1,5-dimethyl-1H-pyrazol-4-carboxaldehyde (41 mg, 0.3 mmol), sodium acetate (25 mg, 0.3 mmol) and acetic anhydride (0.3 mL) were added. The test tube was sealed, and it was then stirred at an external temperature of 90 C. Three hours later, the temperature of the reaction solution was returned to room temperature, and water (1.5 mL) was then added thereto. The obtained mixture was stirred at the same temperature as described above for 1.5 hours. Thereafter, the precipitated crystal was collected by filtration, and it was washed with water (5 mL) and was then dried under reduced pressure, so as to obtain 35 mg of the above-captioned compound. 1H-NMR (400 MHz, DMSO-d6, delta). 8.34 (s, 1H), 8.04 (d, J=4.9 Hz, 1H), 7.90 (d, J=3.7 Hz, 1H), 7.32 (dd, J=3.8, 4.9 Hz, 1H), 7.19 (s, 1H), 3.81 (s, 3H), 2.45 (s, 3H). ESI-MS m/z 274 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.