Reference of 35344-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35344-95-7 name is 1H-Pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 50-mL round-bottom flask was placed a solution of [(ls,3 s)-3 -(3-phenyl- 1 ,2-oxazole-5 -amido)cyclobutyljmethyl 4-methylbenzene- 1 -sulfonate (1g, 2.34 mmol, 1.00 equiv) in DMF (15 mL) then Cs2CO3 (1.5 g, 4.60 mmol, 2.00 equiv) and1H-pyrazole-4-carbaldehyde (338 mg, 3.52 mmol, 1.50 equiv) were added. The resulting solution was stirred for 3 h at 100¡ãC then the solids were removed by filtration. The crude product was purified by Flash-Prep-HPLC (CombiFlash-1: Column, C18 silica gel; mobile phase, X: H20 (0.5percent NH4HCO3), Y: ACN, X/Y=90/10 increasing to X/Y=5/95 within 40 mm;Detector, UV 254 nm) affording 460 mg (56percent) of 3-phenyl-N-[(ls,3s)-3-[(4-formyl-1H- pyrazol-1-yl)methyljcyclobutylj-1,2-oxazole-5-carboxamide as a yellow solid. LCMS (ES, m/z): [M+Hj?= 351.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.