In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 14531-55-6
To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (1.09, 7.09 mmcl) in acetonitrile (10 mL)was added 2,2-dimethyloxirane (1.788 g, 24.80 mmol) and DBU (2.136 mL, 14.17 mmol).The reaction was stirred at 60 C for 20 hours. The mixture was quenched with water and extracted with DCM (20 mL x 3). The combined organic layer was dried over Na2SO4, filtered and concentrated in vacuum. The crude was purified by column chromatography on silica gel (DCM: MeOH2O:1) to give the title compound D5 (800 mg, 3.75 mmol,52.9 %yield).LCMS: 214 [M+H], tRl.O6 mi (LCMS condition 2)
The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.