These common heterocyclic compound, 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1001020-14-9
Example 862-(3-(4-((Methylamino)methyl)-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-4,5,6,7- tetrahydrobenzofblthiophene-3-carboxamidea) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1 -yl)propanamido)-4,5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde (260 mg, 1.585 mmol) and 2-(3- chloropropanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (454 mg, 1.585 mmol) were dissolved in THF (20 mL). Potassium tert-butoxide (356 mg, 3.17 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was stirred at RT overnight. Water was added and the reaction mixture extracted with EtOAc (x 3).The EtOAc layers were combined and washed with brine, dried over MgSO4, filtered and the solvent removed in vacuo to give a yellow gum (673 mg). Purification by flash column chromatography-silica gel gave the desired product as a white solid (180 mg, 0.43 mmol,27 %).MS (ESI) : m/z 415.1 [M + H]+ .
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1001020-14-9.