N-Arylation of pyrazoles with activated aryl ethers was written by Chiriac, Constantin I.;Toma, Ovidiu;Chiriac, Florentina;Lupu, Viorel;Ropot, Radu;Truscan, Ion. And the article was included in Revue Roumaine de Chimie in 1994.Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:
Various N-arylpyrazoles can be prepared by a condensation reaction of pyrazoles and activated aryl ethers, such as 2,4-dinitrophenyl Ph ether and 2,4,6-trinitrophenyl Ph ether, in DMSO as solvent at 155-165鎺?for 1-3 h. The basicity of the pyrazoles and the reactivity of activated aryl ethers are important factors in this reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics