Reactions of 3-(polyfluoroacyl)chromenones with heterocyclic amines: novel synthesis of polyfluoroalkyl-containing fused pyridines was written by Kotljarov, Anton;Iaroshenko, Viktor O.;Volochnyuk, Dmitriy M.;Irgashev, Roman A.;Sosnovskikh, Vyacheslav Ya.. And the article was included in Synthesis in 2009.Computed Properties of C5H9N3 This article mentions the following:
The selectivity of the reactions of 3-(polyfluoroacyl)-4H-chromen-4-ones, e.g. I, with a wide range of aminoheterocycles and arylamines has been evaluated. The method described facilitates access to polyfluoroalkyl-containing fused pyridines, e.g. II. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Computed Properties of C5H9N3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Computed Properties of C5H9N3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics