Shebaldova, A. D. et al. published their research in Russian Journal of Coordination Chemistry (Translation of Koordinatsionnaya Khimiya) in 1995 | CAS: 934-48-5

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.HPLC of Formula: 934-48-5

Features of the complex formation of platinum(II), palladium(II), and cobalt(II) with 3,5-dimethyl-1-carbamidopyrazole was written by Shebaldova, A. D.;Safronova, L. A.. And the article was included in Russian Journal of Coordination Chemistry (Translation of Koordinatsionnaya Khimiya) in 1995.HPLC of Formula: 934-48-5 This article mentions the following:

The interaction of Pt(II), Pd(II), and Co(II) salts with 3,5-dimethyl-1-carbamidopyrazole (HL) was studied. Complexes of various compositions and structures are formed, depending on the nature of the metal, the type of salt, and the ratio between the reagents (M:L = 1:1 or 1:2). In the case of K2MCl4 [M = Pt(II), Pd(II),], M(HL)Cl2 chelate cis complexes with HL coordinated via the pyridine N atom of the cycle and via the N atom of the amino group are formed at the equimolar ratio between the reagents. At the ratio M:HL = 1:2, the PdL2 chelate and the [Pt(HL’)(L’)Cl]2 bridging complex with the product of decarbamoylization of the ligand, namely, 3,5-dimethylpyrazole (HL’), are formed for Pd(II) and Pt(II), resp. In distinction to K2MCl4, the reaction of PdCl2 and CoCl2 with HL leads, in all cases, to the destruction of the ligand and to the formation of ML’2Cl2 complexes. The coordination environment of the metal in the complexes is determined by DTA and IR spectroscopy. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5HPLC of Formula: 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.HPLC of Formula: 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics