Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides was written by Walsh, Thomas F.;Toupence, Richard B.;Young, Jonathan R.;Huang, Song X.;Ujjainwalla, Feroze;DeVita, Robert J.;Goulet, Mark T.;Wyvratt, Matthew J. Jr.;Fisher, Michael H.;Lo, Jane-Ling;Ren, Ning;Yudkovitz, Joel B.;Yang, Yi Tien;Cheng, Kang;Smith, Roy G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Application of 3528-58-3 This article mentions the following:
SAR studies which focused upon the C(6) position of a recently described series of quinolone gonadotropin-releasing hormone antagonists are reported. Synthetic access to diverse quinolone-6-carboxamides was achieved via the Pd-catalyzed aminocarbonylation reactions of a 4-hydroxy-6-iodoquinolone with various amines. 4-Pyrimidinamine-derived amides were especially potent, functional antagonists of rat and human GnRH receptors. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application of 3528-58-3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application of 3528-58-3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics