Thiophene isosteres: synthesis and pharmacological study of 3-(azol-1-yl)thienoisothiazole 1,1-dioxides was written by Vega, Salvador;Madronero, Ramon;Diaz, J. Antonio;Junquera, Francisco;Alonso, Javier;Darias, Victoriano;Bravo, Luis;Abdalah, Suzanne. And the article was included in European Journal of Medicinal Chemistry in 1988.Product Details of 15953-73-8 This article mentions the following:
Three series of new 3-(azol-1-yl)thienoisothiazole 1,1-dioxides, e.g., I (X = S, X1 = CH; X = CH, CPh, X1 = S: R, R1, R2 = H, Cl, Me) were synthesized and tested for antiinflammatory, analgesic and antipyretic activity as well as for acute toxicity. Acetylsalicylic acid was used as the reference standard In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Product Details of 15953-73-8).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 15953-73-8
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics