Bol’but, A. V. et al. published their research in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006 | CAS: 18213-75-7

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.HPLC of Formula: 18213-75-7

Condensed pyrimidine systems. 4. Synthesis and transformations of 6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones was written by Bol’but, A. V.;Korol’ov, O. K.;Vovk, M. V.. And the article was included in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2006.HPLC of Formula: 18213-75-7 This article mentions the following:

1-R-6-Trifluoromethyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones (2a–d; R = Me, PhCH2, Ph, 3-ClC6H4) were prepared by heterocyclization of 5-aminopyrazole-4-carboxamides with Me trifluoroacetate. The pyrimidinones 2 were converted into the corresponding 4-alkoxy, chloro, amino and hydrazino derivatives and 7-R-5-trifluoromethyl-7H-pyrazolo[4,3-e]tetrazolo[1,5-c]pyrimidines (7a–c; R = PhCH2, Ph, 3-ClC6H4). In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7HPLC of Formula: 18213-75-7).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.HPLC of Formula: 18213-75-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics