Nitropyrazoles. 4. N-Amination under pH control was written by Vinogradov, V. M.;Dalinger, I. L.;Gulevskaya, V. I.;Shevelev, S. A.. And the article was included in Izvestiya Akademii Nauk, Seriya Khimicheskaya in 1993.SDS of cas: 5334-39-4 This article mentions the following:
N-amination of pyrazoles bearing nitro groups and other electron-withdrawing substituents with hydroxylamine-O-sulfonic acid under pH control was carried out. A series of previously unknown pyrazoles was prepared Basicities (pKBH+) of 1-aminopyrazole and 1-amino-4-nitropyrazole were measured, and differences in the basicity of C- and N-amino groups for pyrazoles were determined In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4SDS of cas: 5334-39-4).
3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 5334-39-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics