Mass spectrometry of nitroazoles. 4. Ortho effects: the loss of CHO閳?and formaldehyde from methyl-substituted nitrodiazoles was written by Luijten, W. C. M. M.;Van Thuijl, J.. And the article was included in Organic Mass Spectrometry in 1982.Recommanded Product: 5334-39-4 This article mentions the following:
The interaction between Me and NO2 groups in some Me-substituted nitropyrazoles and -imidazoles caused the expulsion of CHO閳?and HCHO during electron-impact mass spectroscopy. This occurred when the 2 substituents were adjacent. Labeling with D and 13C showed that the loss of CHO閳?and HCHO originates exclusively from the substituents. The isotope effects observed in partially deuterated 3(5)-methyl-4-nitropyrazole were consistent with H transfer prior to fragmentation. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Recommanded Product: 5334-39-4).
3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 5334-39-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics