An improved synthesis of 3,6-diamino-1,2,4,5-tetrazine. I was written by Coburn, Michael D.;Ott, Donald G.. And the article was included in Journal of Heterocyclic Chemistry in 1990.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:
Treatment of 1,3-diaminoguanidine monohydrochloride with 2,4-pentanedione in alcs. under carefully controlled conditions gave the tetrazine monohydrochloride I in 45-50% yields along with 3,5-dimethyl-1H-pyrazole and its hydrochloride. Oxidation of I with sodium perborate produced 3,6-diamino-1,2,4,5-tetrazine (II) in quant. yield. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics