4-Nitro-5-(3-pyridyl)pyrazole, a new oxidation product of nicotine. III. Confirmatory synthetical experiments was written by Gough, Geo. A. C.;King, Harold. And the article was included in Journal of the Chemical Society in 1933.Application of 45887-08-9 This article mentions the following:
The by-product in the oxidation of nicotine to nicotinic acid, 4-nitro-5-(3-pyridyl)pyrazole (C. A. 26, 990), gives the 4-NH2 derivative, which on deamination gives 3-(5-pyridyl)pyrazole (I), whose picrate, crystals with 1 H2O, m. 194-5°, methiodide, m. 217.5°, methopicrate, m. 185°, flavianate, crystals with 2 H2O, orange, m. 229° (decomposition). β-Pyridoylacetone and N2H4 give quant. 3-methyl-5-(3-pyridyl)pyrazole, crystals with 1.5 H2O, m. 81-3°, and then 137-8°; picrate, m. 202-3°; HCl salt, m. 214-6°; oxidation with KMnO4 gives 5-(3-pyridyl)pyrazole-3-carboxylic acid, m. 308-10° (decomposition); picrate, m. 242-5°; heating at 310° gives I. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Application of 45887-08-9).
3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 45887-08-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics