5-Aminopyrazoles synthesis was written by Hoehn, Hans. And the article was included in Zeitschrift fuer Chemie in 1970.HPLC of Formula: 3528-58-3 This article mentions the following:
1-(R-Substituted)-5-aminopyrazoles and their 3-methyl and 4-methyl derivatives (57 compounds where R = aliphatic, cycloaliphatic, aralkyl, 2-furylmethyl, or 2-thienylmethyl) were prepared by treating CHR1:CR2CN (R1 = H, Me, etc., R2 = H, Me, Et) with N2H4 to give NH2NHCHR1CHR2CN, adding aldehyde or ketone R3R4CO to give R3CR4:NNHCHR1CHR2CN and treating the hydrazone with BuONa for 2-5 hr at 90-130°. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3HPLC of Formula: 3528-58-3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 3528-58-3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics