Synthesis of new heterocycles by using thiocarbohydrazide and thiosemicarbazides was written by Chande, Madhukar S.;Pankhi, Mohd Aslam;Ambhaikar, Shireesh B.. And the article was included in Indian Journal of Chemistry in 2000.Product Details of 51395-52-9 This article mentions the following:
3-Amino-2-alkyl/arylimino-5-carbethoxy-thiazolidin-4-ones, 2-hydrazino-6-carbethoxy-4H,6H-1,3,4-thiadiazin-5-one, 2-hydrazino-7-substituted, 5,7-disubstituted-4H-pyrazolo[5,4-e]1,3,4-thiadiazines and 2-hydrazino-7-phenyl-4H-isoxazolo[5,4-e]-1,3,4-thiadiazine have been synthesized. The compounds have been characterized by chem. reactions, alternate syntheses and spectral data. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Product Details of 51395-52-9).
4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 51395-52-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics