Ferroni, R. et al. published their research in Arzneimittel-Forschung in 1990 | CAS: 18213-75-7

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.SDS of cas: 18213-75-7

Cyclic guanidines: synthesis and antiplatelet activity of 4,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyrazolo[3,4-d]pyrimidin-7-ones and 1,4,6,7,8,9-hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1-c][1,2,4]triazin-7-ones was written by Ferroni, R.;Simoni, D.;Orlandini, P.;Bardi, A.;Franze, G. P.;Guarneri, M.. And the article was included in Arzneimittel-Forschung in 1990.SDS of cas: 18213-75-7 This article mentions the following:

I (R = e.g., Me, Ph, 4-ClC6H4, R1 = Bu, benzyl, or H) and II (R = e.g., Me, Ph, 4-ClC6H4) were prepared starting from 5-amino-4-cyano-1-(2,5-dichlorophenyl)pyrazole through a series of reactions. The compounds were tested for inhibition against blood platelet aggregation induced by ADP or collagen. Among the compounds tested I (R = 2,5-dichlorophenyl, R1 = CH2Ph), showed the highest activity. An increase in lipophilicity of the substituent was accompanied by an increase in the platelet aggregation inhibitory activity. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7SDS of cas: 18213-75-7).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.SDS of cas: 18213-75-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics