Excited-State Intramolecular Proton Transfer in Five-Membered Hydrogen-Bonding Systems: 2-Pyridyl Pyrazoles was written by Yu, Wei-Shan;Cheng, Chung-Chih;Cheng, Yi-Ming;Wu, Pei-Chi;Song, Yi-Hwa;Chi, Yun;Chou, Pi-Tai. And the article was included in Journal of the American Chemical Society in 2003.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:
The excited-state intramol. proton transfer (ESIPT) reaction in five-membered N-H···N hydrogen-bonding systems has been explored through design and syntheses of a series of 5-(2-pyridyl)-1-H-pyrazoles. The ESIPT mechanism was confirmed through spectroscopy, relaxation dynamics, and corresponding methylated analogs. The results demonstrate for the first time a unique system among ESIPT mols., in which ESIPT incorporates an appreciably large energy barrier fine-tuned by the skeletal reorganization. This makes 5-(2-pyridyl)-1-H-pyrazole systems ideal models for probing the reaction potential energy surface. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).
2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics