Rimland, Joseph et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. SDS of cas: 3528-58-3

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist was written by Rimland, Joseph;Dunne, Angela;Hunjan, Suchete S.;Sasse, Rosemary;Uings, Iain;Montanari, Dino;Caivano, Matilde;Shah, Poonam;Standing, David;Gray, David;Brown, David;Cairns, William;Trump, Ryan;Smith, Paul W.;Bertheleme, Nicolas;D’Alessandro, Pier;Gul, Sheraz;Vimal, Mythily;Smith, David N.;Watson, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.SDS of cas: 3528-58-3 This article mentions the following:

The identification of novel, potent, non-steroidal/small mol. functional GR antagonist GSK1564023A (I) selective over PR is described. Associated structure-activity relationships and the process of optimization of an initial HTS hit are also described. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3SDS of cas: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. SDS of cas: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics