Chan-Lam cross-coupling reactions promoted by anionic copper(I)/iodide species with cationic methyl-((pyridinyl)-pyrazolyl)pyridin-1-ium was written by Xue, Jiang-Yan;Li, Jun-Chi;Li, Hong-Xi;Li, Hai-Yan;Lang, Jian-Ping. And the article was included in Tetrahedron in 2016.HPLC of Formula: 45887-08-9 This article mentions the following:
Four anionic ligands including 1-methyl-3(or 4)-(1-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridin-1-ium iodide ([3,2′-pypzpym]I, [4,2′-pypzpym]I) and 1-methyl-3(or 4)-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)pyridin-1-ium iodide ([2,3′-pypzpym]I, [2,4′-pypzpym]I) were prepared Reaction of CuI with [3,2′-pypzpym]I afforded a mononuclear complex [CuI2(3,2′-pypzpym)] and a one-dimensional coordination polymer [(Cu4I6)(3,2′-pypzpym)2]n. Analogous reactions of CuI with [4,2′-pypzpym]I, [2,3′-pypzpym]I or [2,4′-pypzpym]I yield [Cu4I6(4,2′-pypzpym)2], [CuI2(2,3′-pypzpym)] and [CuI2(2,4′-pypzpym)], resp. Relative to that of CuI, complexes exhibited enhanced catalytic activities towards the Chan-Lam cross-coupling reactions of imidazoles and arylboronic acids in a H2O-MeCN (volume/volume=2:1). This catalytic system was involved in the C-N cross-coupling reaction and works for a variety of imidazole derivatives as well as arylboronic acids with different electronic properties. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9HPLC of Formula: 45887-08-9).
3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.HPLC of Formula: 45887-08-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics