Oxidative transformation of N-substituted 3-aminopyrazoles to azopyrazoles using electrogenerated bromine as a mediator was written by Lyalin, B. V.;Sigacheva, V. L.;Kokorekin, V. A.;Dutova, T. Ya.;Rodionov, G. M.;Petrosyan, V. A.. And the article was included in Russian Chemical Bulletin in 2018.Computed Properties of C5H9N3 This article mentions the following:
The one-pot process of anodic transformation of N-alkyl-3-aminopyrazoles into azopyrazoles I [R1 = H, Me, Et; R2 = H, Me; R3 = Br, Me] under conditions of membraneless electrolysis in an aqueous solution of NaBr was studied for the first time. It was found that under these conditions the aminopyrazoles, which do not have a substituent at position 4, transform into the corresponding 4,4′-dibromoazopyrazoles. The corresponding yield was in the interval of 28-80%, depending on the structure of the products. The transformation of 4-substituted aminopyrazoles resulted in the formation of azopyrazoles in the yields lying within 62-86% when this process was implemented under conditions with the anodically generated Br2 acting as a mediator. A convenient method of anodic synthesis of azopyrazoles in an aqueous medium without the use of additives of chem. oxidants was proposed. The process was environmentally sound and was characterized by a high atom efficiency (>85%). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4Computed Properties of C5H9N3).
1-Ethyl-1H-pyrazol-3-amine (cas: 55361-49-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Computed Properties of C5H9N3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics