Organic reactions in the aqueous medium. Part VI. Synthesis of substituted pyrazoles and pyrazolones was written by Ali, Sh. Shaukat;Ashraf, C. M.;Younas, M.;Ehsan, A.. And the article was included in Pakistan Journal of Scientific and Industrial Research in 1993.Recommanded Product: 934-48-5 This article mentions the following:
The reactions of semicarbazide hydrochloride and hydrazine monohydrate with Et acetoacetate, acetylacetone, benzoylacetone, and dibenzoylmethane leading to the formation of pyrazole and pyrazolone derivatives have been intensively studied in aqueous as well as in nonaqueous medium under various sets of conditions. This has resulted in the development of simple and convenient methods for the synthesis of pure Et acetoacetate semicarbazone, 3-methylpyrazol-5-one-1-carboxamide, 3-methylpyrazol-5-one, 3,5-dimethylpyrazole-1-carboxamide, 3,5-dimethylpyrazole, 3-phenyl-5-methylpyrazole-1-carboxamide, 3-phenyl-5-methylpyrazole, and 3,5-diphenylpyrazole. It has been suggested that the reaction of semicarbazide hydrochloride with β-diketo compounds proceeds through four stages. A reaction scheme has been proposed to explain the formation of different products. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 934-48-5).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 934-48-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics