Biaryl substituted hydantoin compounds as TACE inhibitors was written by Yu, Wensheng;Tong, Ling;Kim, Seong Heon;Wong, Michael K. C.;Chen, Lei;Yang, De-Yi;Shankar, Bandarpalle B.;Lavey, Brian J.;Zhou, Guowei;Kosinski, Aneta;Rizvi, Razia;Li, Dansu;Feltz, Robert J.;Piwinski, John J.;Rosner, Kristin E.;Shih, Neng-Yang;Siddiqui, M. Arshad;Guo, Zhuyan;Orth, Peter;Shah, Himanshu;Sun, Jing;Umland, Shelby;Lundell, Daniel J.;Niu, Xiaoda;Kozlowski, Joseph A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Related Products of 73387-46-9 This article mentions the following:
We disclose further optimization of hydantoin TNF-α convertase enzyme (TACE) inhibitors. SAR with respect to the non-prime region of TACE active site was explored. A series of biaryl substituted hydantoin compounds was shown to have sub-nanomolar K i, good rat PK, and good selectivity vs. MMP-1, -2, -3, -7, -9, and -13. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Related Products of 73387-46-9).
3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Related Products of 73387-46-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics