Substituent-oriented C-N bond formation via N-H insertion or Wolff rearrangement of 5-aryl-1H-pyrazoles and diazo compounds was written by Zuo, Youpeng;He, Xinwei;Ning, Yi;Tang, Qiang;Xie, Mengqing;Hu, Wangcheng;Shang, Yongjia. And the article was included in Organic & Biomolecular Chemistry in 2019.Formula: C9H7BrN2 This article mentions the following:
A facile and efficient synthetic strategy for the chemoselective synthesis of N-substituted 3-aryl-1H-pyrazole derivatives was developed and it was oriented by different 2-diazo compounds Both N-H insertion and Wolff-rearrangement products were obtained selectively by the opportune choice of diazo compounds N-Cyclohexenone 3-aryl-1H-pyrazoles were formed using cyclic 2-diazo-1,3-diketones via N-H insertion in the presence of a copper catalyst and α-carbonyl 3-aryl-1H-pyrazoles were be synthesized through a Wolff-rearrangement process without any catalyst under thermal conditions. Moreover, both reactions were carried out in moderate to excellent yields (58-93%) and showed good functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Formula: C9H7BrN2).
3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Formula: C9H7BrN2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics