Ryabukhin, Sergey V. et al. published their research in ACS Combinatorial Science in 2012 | CAS: 141459-53-2

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C8H15N3

High Throughput Synthesis of Extended Pyrazolo[3,4-d]dihydropyrimidines was written by Ryabukhin, Sergey V.;Granat, Dmitry S.;Plaskon, Andrey S.;Shivanyuk, Alexander N.;Tolmachev, Andrey A.;Volovenko, Yulian M.. And the article was included in ACS Combinatorial Science in 2012.Electric Literature of C8H15N3 This article mentions the following:

Fused pyrazolo[3,4-d]pyrimidines such as I (R = Ph, 4-MeOC6H4, 4-ClC6H4, 5-phenyl-2-furanyl, 1-phenyl-4-pyrazolyl, 3,4-Me2C6H3, 3-F3CC6H4, 3-Me-2-thienyl, 3-ClC6H4, 5-Me-2-furanyl, 3,5-dimethyl-4-isoxazolyl, 3,4-Cl2C6H3, 2-FC6H4, 3-FC6H4, 4-Me2NC6H4, 2-F2CHOC6H4; R1 = H; R2 = H, F3C, Me2NSO2, 1-pyrrolidinylsulfonyl, 1-piperidinylsulfonyl, 4-morpholinylsulfonyl; R1R2 = benzo) were prepared in two steps from 1-substituted-5-pyrazoleamines such as 1-isopropyl-5-pyrazoleamine, heteroaryl chlorides such as 2-chloropyridine, and aldehydes such as benzaldehyde. N-heteroaryl 5-pyrazoleamines such as II (R1 = H; R2 = H, F3C, 1-piperidinylsulfonyl; R1R2 = benzo) were generated by base-mediated condensation of 5-pyrazoleamines such as 1-phenyl-3-methyl-5-pyrazoleamine with heteroaryl chlorides such as 2-chloropyridine; heating the heteroaryl pyrazoleamines with aryl aldehydes or isatins either in a sealed tube with trimethylsilyl chloride or in glacial acetic acid followed by crystallization yielded pyrazolo[3,4-d]pyrimidines. Reaction of N-heteroaryl 5-pyrazoleamines with cyclohexanone provided N-heteroaryl 4-(1-cyclohexen-1-yl)-5-pyrazoleamines rather than spirocyclohexanepyrazolopyrimidines. A library of > 200 pyrazolo[3,4-d]pyrimidines were prepared; the distribution of the library members within ranges of lipophilicity, mol. weight, hydrogen bond acceptor and donor count, and polar surface area was determined In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Electric Literature of C8H15N3).

1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C8H15N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics