One-pot Synthesis of Substituted Pyrazoles from Propargyl Alcohols via Cyclocondensation of in situ-Generated α-Iodo Enones/Enals and Hydrazine Hydrate was written by Guo, Huifeng;Zhang, Qinglin;Pan, Wanyong;Yang, Hong;Pei, Keke;Zhai, Jiulong;Li, Tiantian;Wang, Zhihai;Wang, Yan;Yin, Yan. And the article was included in Asian Journal of Organic Chemistry in 2021.COA of Formula: C9H7BrN2 This article mentions the following:
An efficient Bi(OTf)3-catalyzed transformation of unprotected propargylic alcs. has been developed, affording a general, one-pot approach to access diverse pyrazoles via sequential iodo-intercepted Meyer-Schuster rearrangement, cyclocondensation of NH2NH2·H2O and α-iodo enones/enals generated in situ, and iodine elimination. This transformation tolerates a wide range of substrates and is reliable on a large scale. The high yields and convenient exptl. operations make it a valuable method for the construction of pyrazole derivatives In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9COA of Formula: C9H7BrN2).
3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.COA of Formula: C9H7BrN2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics