Versatile synthesis of 6-alkyl(aryl)-1H-pyrazolo[3,4-d]pyrimidin-4[5H]-ones was written by Reddy, K. Hemender;Reddy, A. Panduranga;Veeranagaiah, V.. And the article was included in Indian Journal of Chemistry in 1992.Computed Properties of C5H8N4O This article mentions the following:
Condensation of 5-amino-1H-pyrazole-4-carboxamide (I, R = H) with various aromatic aldehydes furnishes 6-substituted 1H-pyrazole[3,4-d]pyrimidin-4(5H)-ones II (R1 = Ph, substituted Ph) via the intermediate 5-(N-arylideneamino)pyrazole-4-carboxamides. II were also synthesized by the reaction of I (R = H) with aromatic carboxylic acids in polyphosphoric acid (PPA) or polyphosphate ester (PPE). Similar treatment of I (R = Ph, Me) with aromatic aldehydes and aromatic carboxylic acids gives exclusively 6-substituted 1-methyl/phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones. The title compounds have were also synthesized by the reaction of I with arylideneanilines. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Computed Properties of C5H8N4O).
5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Computed Properties of C5H8N4O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics