Heterocycle synthesis through reactions of nucleophiles with acrylonitriles. 12. A new route for the synthesis of pyrano[3,2-d]pyrimidines and pyrano[2,3-c]pyrazoles was written by Abdel-Latif, Fathy Fahim. And the article was included in Indian Journal of Chemistry in 1991.HPLC of Formula: 51395-52-9 This article mentions the following:
A new route for the synthesis of pyranopyrimidines I (X = O, S; Ar = Ph, 2-furyl, 2-thienyl, 4-pyridyl) through the reaction of barbituric acid or thiobarbituric acid with ArCH:CRR1 (II; R = CN; R1 = CO2Et) is reported. A similar reaction of II (R = R1 = CN) gave ylidenes III. The reaction of bromomethylpyrazolinone IV with II (Ar = 2-thienyl; R = R1 = CN) gave pyranopyrazole V. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9HPLC of Formula: 51395-52-9).
4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.HPLC of Formula: 51395-52-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics