Shestopalov, A. M. et al. published their research in Chemistry of Heterocyclic Compounds in 2002 | CAS: 401-73-0

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C4H3F3N2O

Synthesis of substituted 6-amino-4-aryl-5-cyano-2H,4H-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2′,4′,6′-triethylphenyl)-2H,4H-pyrano[2,3-c]pyrazole was written by Shestopalov, A. M.;Yakubov, A. P.;Tsyganov, D. V.;Emel’yanova, Yu. M.;Nesterov, V. N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2002.Synthetic Route of C4H3F3N2O This article mentions the following:

Substituted 6-aminopyrano[2,3-c]pyrazoles I [R = Me, Et, n-Pr, tert-Bu, Ph, CF3, MeOCH2, MeOCOCH2, 4-MeC6H4SCH2; R1 = 2,4,6-Me3C6H2, 2,4,6-Me3-3-O2NC6H, 2,4,6-Me3-3,5-(O2N)2C6, 2,4,6-Me3-3-(EtOCH2)C6H, 2,4,6-Et3C6H2, 2,5-(MeO)2C6H3, 2,3,4-, 2,4,5-(MeO)3C6H2, 2-F3C-, 2-MeC6H4, 2-(2-ClC6H4CH2O)C6H4, 2-thienyl, 2-furanyl, 3-pyridinyl] were synthesized by the two-component condensation of arylidenemalononitriles, R1CH:C(CN)2, and pyrazolones II or by the three-component condensation of aromatic aldehydes, R1CHO, malononitrile, and pyrazolones II. It was established by X-ray crystallog. anal. that pyranopyrazoles exist in the 2H and not the 1H tautomeric form. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Synthetic Route of C4H3F3N2O).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Synthetic Route of C4H3F3N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics