As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 131797-35-8 name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 131797-35-8
Step 5: 6J-Dichloro-2-[[5-chloro-3-(trifluoromethyl)-lH-pyrazol-l-yllmethyll-4H-pyrido[l,2- alpyrimidin-4-one To a solution of 6,7-dichloro-2-(chloromethyl)-4H-pyrido[l,2-a]pyrimidin-4-one (1 g, 3.80 mmol) in acetonitrile (50 mL) was added 5-chloro-3-(trifluoromethyl)-lH-pyrazole (519 mg, 3.04 mmol), potassium iodide (317 mg, 1.91 mmol) and potassium carbonate (1.05 g, 7.60 mmol). The reaction was stirred for 1 h at 80C. Then the resulting mixture was concentrated in vacuo. The residue was purified by chromatography with ethyl acetate/petroleum ether (1/9) to afford 6,7-dichloro-2-[[5-chloro-3-(trifluoromethyl)-lH-pyrazol- 1- yl]methyl]-4H-pyrido[l,2-a]pyrimidin-4-one (600 mg, 40%) as yellow oil. LCMS (ESI): M+H+ = 397.1 ; HNMR (300 MHz, CDC13) delta 7.60 (d, J = 4.8 Hz, 1H), 7.34 (d, J = 4.8 Hz, 1H), 6.60 (s, 1H), 5.85 (s, 1H), 5.31 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.