High Throughput Synthesis of Extended Pyrazolo[3,4-d]dihydropyrimidines was written by Ryabukhin, Sergey V.;Granat, Dmitry S.;Plaskon, Andrey S.;Shivanyuk, Alexander N.;Tolmachev, Andrey A.;Volovenko, Yulian M.. And the article was included in ACS Combinatorial Science in 2012.Application In Synthesis of 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:
Fused pyrazolo[3,4-d]pyrimidines such as I (R = Ph, 4-MeOC6H4, 4-ClC6H4, 5-phenyl-2-furanyl, 1-phenyl-4-pyrazolyl, 3,4-Me2C6H3, 3-F3CC6H4, 3-Me-2-thienyl, 3-ClC6H4, 5-Me-2-furanyl, 3,5-dimethyl-4-isoxazolyl, 3,4-Cl2C6H3, 2-FC6H4, 3-FC6H4, 4-Me2NC6H4, 2-F2CHOC6H4; R1 = H; R2 = H, F3C, Me2NSO2, 1-pyrrolidinylsulfonyl, 1-piperidinylsulfonyl, 4-morpholinylsulfonyl; R1R2 = benzo) were prepared in two steps from 1-substituted-5-pyrazoleamines such as 1-isopropyl-5-pyrazoleamine, heteroaryl chlorides such as 2-chloropyridine, and aldehydes such as benzaldehyde. N-heteroaryl 5-pyrazoleamines such as II (R1 = H; R2 = H, F3C, 1-piperidinylsulfonyl; R1R2 = benzo) were generated by base-mediated condensation of 5-pyrazoleamines such as 1-phenyl-3-methyl-5-pyrazoleamine with heteroaryl chlorides such as 2-chloropyridine; heating the heteroaryl pyrazoleamines with aryl aldehydes or isatins either in a sealed tube with trimethylsilyl chloride or in glacial acetic acid followed by crystallization yielded pyrazolo[3,4-d]pyrimidines. Reaction of N-heteroaryl 5-pyrazoleamines with cyclohexanone provided N-heteroaryl 4-(1-cyclohexen-1-yl)-5-pyrazoleamines rather than spirocyclohexanepyrazolopyrimidines. A library of > 200 pyrazolo[3,4-d]pyrimidines were prepared; the distribution of the library members within ranges of lipophilicity, mol. weight, hydrogen bond acceptor and donor count, and polar surface area was determined In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application In Synthesis of 1-Ethyl-1H-pyrazol-5-amine).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 1-Ethyl-1H-pyrazol-5-amine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics