Greener and facile aqueous synthesis of pyrazoles using Amberlyst-70 as a recyclable catalyst was written by Chandak, Hemant S.;Lad, Nitin P.;Dange, Dipali S.. And the article was included in Green Chemistry Letters and Reviews in 2012.Category: pyrazoles-derivatives This article mentions the following:
An environmentally benign, room temperature aqueous synthesis of pyrazoles by the condensation of hydrazines/hydrazides with 1,3-diketones using Amberlyst-70 as a recyclable catalyst was described. The use of resinous, non-toxic, thermally stable and inexpensive Amberlyst-70 as a heterogeneous catalyst and simple reaction workup are the addnl. eco-friendly attributes of this synthetic protocol. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Category: pyrazoles-derivatives).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics