‘On water’ highly atom economical and rapid synthesis of a novel class of 3-hydroxy-2-oxindole scaffolds under a catalyst-free and column chromatography-free protocol at room temperature was written by Thakur, Pramod B.;Meshram, Harshadas M.. And the article was included in RSC Advances in 2014.Computed Properties of C4H3F3N2O This article mentions the following:
An ‘on water’ highly atom economical and rapid protocol has been developed for the synthesis of 3-(2-pyrazolin-5-one) substituted, 3-hydroxy-2-oxindole scaffolds I (R1 = H, C6H5; R2 = H, Cl; R3 = F, NO2, CH3, Cl, H, I; R4 = H, Cl, CH3; R5 = H, CH3, CH2CH2CH3) under catalyst-free and column chromatog.-free conditions at rt. The generality of the method has been demonstrated by screening a series of isatin electrophiles as well as 2-pyrazolin-5-one derivatives The developed method is a good example of green synthesis in which straightforward synthesis of a medicinally important 3-hydroxy-2-oxindole framework is executed by employing very mild, simple and handy procedures from readily available starting materials. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Computed Properties of C4H3F3N2O).
3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Computed Properties of C4H3F3N2O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics