Metabolic control in hypoglycemic therapy with pyrazole derivatives was written by Bacleseanu, Cornelia;Cojocaru, Zenaida;Nistor, Constantin. And the article was included in Studii si Cercetari de Biochimie in 1973.Electric Literature of C6H9N3O This article mentions the following:
The hepatic lactic acid [50-21-5] content in rats was decreased by the i.v. administration of tolbutamine [64-77-7], Maguan [Me2NC(:NH)NHC(:NH)NH2-HCl] or 3,5-dimethylpyrazole (I) [67-51-6] at 125 mg/kg, or of 4 IU insulin [9004-10-8]/kg. Maguan, and to a lesser extent tolbutamine and I decreased the hepatic pyruvic acid [127-17-3]. The liver hexokinase [9001-51-8] activity was increased markedly by tolbutamine and I, moderately by 1-carbamido-3,5-dimethylpyrazole (II) [934-48-5], and was decreased by Maguan. The aldolase [9024-52-6] activity was increased by I and was decreased by II and Maguan. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Electric Literature of C6H9N3O).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Electric Literature of C6H9N3O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics