Syntheses with silver or sodium pyrazoles. III. Reactions of sodium pyrazoles was written by Reimlinger, Hans;Noels, Alfred;Jadot, Josef;Van Overstraeten, Andre. And the article was included in Chemische Berichte in 1970.Application of 934-48-5 This article mentions the following:
Reaction of the Na salt of pyrazole with BrCN gave 2,4,6-tripyrazol-1-yl-s-triazine. Similar reaction of substituted 3,5-dimethylpyrazoles (I) (where R = Na and R1 = H or Me) gave I (where R = CN and R1 = H or Me) (II). Hydrolysis of II yielded I (R = CONH2 and R1 = H or Me) and I (R = H and R1 = H or Me). The Na salts of 4-chloro- or 4-bromopyrazole reacted with BrCN to give iminobis(4-chloropyrazol-1-yl)- or iminobis(4-bromopyrazol-1-yl)methane. Reaction of the Na salt of pyrazole with PhNCO gave 1-phenylcarbamoylpyrazole. Similar reaction of the Na salts of pyrazole or I with CHCCH2Br gave 35-76% trisubstituted 1-propargylpyrazoles (III) (R, R1, R2 = H or Me). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Application of 934-48-5).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 934-48-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics