Nitrogen systems. VII. The kinetics of ethanolysis of 1-acylpyrazoles was written by Scott, F. L.. And the article was included in Chimia in 1957.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:
The ethanolysis rate constants of a number of 1-acylpyrazoles, determined spectrophotometrically, are tabulated, and the possible reaction mechanisms are discussed on the basis of these figures. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics