Chiral Magnesium(II) Complex-Catalyzed Enantioselective Desymmetrization of meso-Aziridines with Pyrazoles was written by Li, Xiangqiang;Guo, Jing;Lin, Lili;Hu, Haipeng;Chang, Fenzhen;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Advanced Synthesis & Catalysis in 2017.Electric Literature of C4H5N3O2 This article mentions the following:
A highly enantioselective catalytic protocol for the desymmetrization of meso-aziridines via ring-opening with pyrazoles was reported using an N,N’-dioxide-Mg(OTf)2 complex as the catalyst. The corresponding trans-α-pyrazole-substituted amines were obtained in good yields and enantioselectivities (up to 99% yield and 94% ee) under mild reaction conditions. Moreover, a remarkably high asym. amplification was observed in the catalytic system. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Electric Literature of C4H5N3O2).
3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C4H5N3O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics