Gomez-Guillen, Manuel et al. published their research in Carbohydrate Research in 1989 | CAS: 10199-53-8

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid

New pentahydroxypentylpyrazoles from the reactions of D-mannose and D-galactose methylhydrazones with nitroalkenes was written by Gomez-Guillen, Manuel;Hans-Hans, Felisa;Lassaletta Simon, Jose Maria;Martin-Zamora, Maria Eloisa. And the article was included in Carbohydrate Research in 1989.Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid This article mentions the following:

Reaction of methylhydrazones I (R = OH, R1 = H; R = H, R1 = OH) with nitroalkenes O2NCR2:CHR3 (R2 = H, Me, R3 = Ph; R2 = H, Me, R3 = p-tolyl) in DMF-H2O gave 50-75% the corresponding pyrazoles II. Structures of II were confirmed by O-acetylation, oxidation of the side-chain to CHO or CO2H groups, and UV and NMR spectral studies. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Application In Synthesis of 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics