t-Butyl as a pyrazole protecting group: preparation and use of 1-tert-butyl-3-methyl-1H-pyrazol-5-amine was written by Pollock, Patrick M.;Cole, Kevin P.. And the article was included in Organic Syntheses in 2012.Name: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine This article mentions the following:
Pyrazole I was prepared in one step from the cyclocondensation reaction of t-butylhydrazine hydrochloride with 3-aminocrotononitrile. Application of I in the preparation N-(5-methyl-1H-pyrazol-3-yl)-2-pyridinamine was demonstrated. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2Name: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine).
1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine (cas: 141459-53-2) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Name: 1-(tert-Butyl)-3-methyl-1H-pyrazol-5-amine
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics