Pyrazoles. XXXVI. Chromatography of pyrazoles in unfixed thin layer of aluminum oxide was written by Kost, A. N.;Faizova, G. K.;Grandberg, I. I.. And the article was included in Zhurnal Obshchei Khimii in 1963.COA of Formula: C5H7ClN2 This article mentions the following:
The Rf values are tabulated for 48 substituted pyrazoles in thin layer Al2O3 chromatography. Solvent system of petr. ether-CHCl3 was satisfactory for separation of 1-alkylpyrazoles; pyrazoles without 1-substituent moved but little in this system, but gave good movement in systems such as C6H6-MeOH or C6H6-Me2CO. Mixtures of isomeric substituted pyrazoles were effectively separated by this procedure. Some difficulty was encountered in separation of 1-phenyl-3- and -4-halopyrazoles only. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8COA of Formula: C5H7ClN2).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C5H7ClN2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics