Structure-action relationship of histamine analogs. 1. Histamine-like compounds with cyclized side chain was written by Schunack, W.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1973.Application of 45887-08-9 This article mentions the following:
Reaction of 2-, 3-, and 4-(2-aminoacetyl)pyridine with KSCN and HNO3 oxidation of the resulting 2-mercapto-4-imidazolyl derivatives gave the imidazolyl derivatives I (Py = 2-, 3-, or 4-pyridyl), which were hydrogenated over 5% Rh/C to give 88-90% of the corresponding piperidines II (X = 2-, 3-, or 4-piperidyl). Hydrogenation of 4-(2-, 3-, and 4-aminophenyl)imidazole, prepared by Raney Ni hydrogenation of the nitro analogs, over 5% Rh/C gave 82-92% (aminocyclohexyl)imidazoles II (X = 2-, 3-, or 4-aminocyclohexyl). Similarly, 2-(3-piperidyl)pyridine (III) and 3-(3-piperidyl)pyrazole (IV) were prepared II (X = 3-piperidyl and 2-aminocyclohexyl) and III and IV had histamine-like activity. Structure-activity relationships of histamine analogs with cyclized side chain are reported. In the experiment, the researchers used many compounds, for example, 3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9Application of 45887-08-9).
3-(1H-Pyrazol-3-yl)pyridine (cas: 45887-08-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 45887-08-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics