Synthesis of 4-aryl-1-ethyl-7-methyl-1,9-dihydropyrano[4,3-b]pyrazolo[4,3-e]pyridin-5(4H)-one via a three-component condensation was written by Hassanabadi, Alireza;Khandan-Barani, Khatereh;Saffari, Jilla. And the article was included in Journal of Chemical Research in 2016.Computed Properties of C5H9N3 This article mentions the following:
An efficient synthesis of a series of 4-aryl-1-ethyl-7-methyl-1,9-dihydropyrano[4,3-b]pyrazolo[4,3-e]pyridin-5(4H)-one I [Ar = C6H5, 4-ClC6H4, 4-BrC6H4, etc.] was reported via condensation of benzaldehydes, 4-hydroxy-6-methyl-2H-pyran-2-one and 1-ethylpyrazol-5-amine in the presence of 10 mol% mol. I2 in ethanol under reflux conditions through a one-pot reaction. The present method uses a metal-free catalyst, is inexpensive and high yielding, and is environmentally acceptable. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Computed Properties of C5H9N3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Computed Properties of C5H9N3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics