Reaction of 2-aminobenzamide analogs and 2-aminothiophenol with ethyl 3-ethoxymethylene-2,4-dioxovalerate. Synthesis of pyrrolo[1,2-a]quinazoline and pyrrolo[1,2-a]benzothiazoline derivatives was written by Kurihara, Takushi;Tani, Tsutomu;Maeyama, Sigeru;Sakamoto, Yasuhiko. And the article was included in Journal of Heterocyclic Chemistry in 1980.Computed Properties of C5H8N4O This article mentions the following:
The reaction of EtOCH:C(COMe)COCO2Et (I) with 2-H2NC6H4CXNHR (X = O, R = H, Me; X = S, R = H) and 3-amino-2-methyl- or phenylpyrazole-4-carboxamides produced Et 3-aminomethylene-2,4-dioxovalerates, which led to pyrrolo[1,2-a]quinazoline-1,5-diones (II) and pyrrolo[1,2-a]pyrazolo[4,3-e]pyrimidine-1,5-dione (III) under the acidic conditions. Analogously, 2-H2NC6H4SH reacted with I to give 2-HSC6H4NHCH:C(COMe)COCO2Et, which was converted to pyrrolo[1,2-a]benzothiazolin-1-one under the neutral conditions. Furthermore, the heterocyclic steroidal mols. IV and V (R1 = H, Me, Ph) were prepared by condensation of II and III with R1NHNH2. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Computed Properties of C5H8N4O).
5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Computed Properties of C5H8N4O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics