Investigation of azoles. N-Carbamoylpyrazoles was written by Elguero, Jose;Jacquier, Robert. And the article was included in Compt. Rend. in 1965.Category: pyrazoles-derivatives This article mentions the following:
A series of 3- and 5-methyl-1-carbamoylpyrazoles, obtained from H2NCONHNH2.HCl with various acetoacetaldehyde derivatives, were identified by their N.M.R. and uv spectra. Several symmetrically substituted N-carbamoylpyrazoles were also studied. 1-Carbamoylpyrazole (I), m. 140-1°, with Br in CHCl3 gave the 4-Br derivative of I, m. 187-9° (EtOH). 3,5-Dimethyl-1-carbamoylpyrazole, m. 113.5°, gave similarly the 4-Br derivative, m. 152-3°. The mixture, m. 98-9°, obtained from H2NCONHNH2.HCl with (MeO)2CHCH2Ac, contained, according to its N.M.R. spectrum, 40% 3-Me derivative of I and 60% 5-Me derivative of I, and according to its uv spectrum 43 and 57%, resp. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Category: pyrazoles-derivatives).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics