Anticancer agents. X. Cyclization of 1-acyl-4-alkylthiosemicarbazide derivatives to 1,2,4,-triazoline-3-thiones in the presence of hydrazine was written by O’Callaghan, C. N.. And the article was included in Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science in 1974.Recommanded Product: 934-48-5 This article mentions the following:
The triazolethione I [R = Et, Bu, Me(CH2)7, MeCONH] were prepared by cyclization of RCH(CONHNHCSNHMe)2 with H2NNH2. EtO2CCHRCONHNHCSNHMe (R = H, Et, Bu) and H2NNH2 gave the triazolethiones II (R = CH2CONHNH2, CHEtCONHNH2, CHBuCONHNH; R1 = Me). RCONHNHCSNHR1 (R = CH2CO2Et, R1 = Et, PhCH2; R = CO2Et, R1 = Me) and H2NNH2 gave the corresponding hydrazides which were cyclized with NaOH to give II (R = CH2CONHNH2, R1 = Et, PhCH2; R = CONHNH2, R1 = Me). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 934-48-5).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: 934-48-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics