59340-27-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59340-27-1 as follows.
Example N1 ,3,5-Trimethyl-1 H-pyrazole-4-sulfonic acid [2-(2-phenyl-chroman-6-yloxy)-thiazol-5- ylmethyl]-amide33 mg of 1 ,3,5-trimethyl-1 H-pyrazole-4-sulfonic acid chloride (0.16 mmol, 1 .2 eq) were weighted into a reaction tube and dissolved in dry tetrahydrofuran (1 ml). 44 mg of [2-(2-phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]amine (0.13 mmol) in dry tetrahydrofuran (3 ml) and 30 mg triethylamine (0.3 mmol, 2.3 eq) were added, the tube was flushed with argon, closed with a screw cap, and shaken over night at 40 C. 0.008 ml of tris-(2-aminoethyl)amine in 0.5 ml tetrahydrofuran were added, the mixture was shaken for 2 h at room temperature and then evaporated. The residue was dissolved in 2 ml of a mixture of dimethylformamide/trifluoroacetic acid (19: 1 ), filtered, and submitted to preparative reversed phase HPLC purification(water/acetonitrile gradient (+ 0.1 % trifluoroacetic acid)). 1 ,3,5-Trimethyl-1 H- pyrazole-4-sulfonic acid [2-(2-phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-amide was obtained as a white solid (42 mg, 63%).
According to the analysis of related databases, 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride, the application of this compound in the production field has become more and more popular.