Chiral phosphoric acid-catalyzed enantioselective three-component aza-Diels-Alder reactions of aminopyrroles and aminopyrazoles was written by Brioche, Julien;Courant, Thibaut;Alcarez, Lilian;Stocks, Mark;Furber, Mark;Zhu, Jieping;Masson, Geraldine. And the article was included in Advanced Synthesis & Catalysis in 2014.Name: 3-Methyl-4-nitro-1H-pyrazole This article mentions the following:
A highly stereoselective three-component Povarov reaction, catalyzed by (R)- and (S)-BINOL hydrogen phosphate, was achieved for the first time with aminopyrroles and aminopyrazoles as 2-azadiene precursors. A variety of aldehydes, enecarbamates, amino-substituted azines participated in the reaction to afford the tetrahydropyrrolopyridines and tetrahydropyrazolopyridines in good yields with excellent diastereo- and enantioselectivities. A stereochem. model was proposed to account for the observed absolute stereochem. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4Name: 3-Methyl-4-nitro-1H-pyrazole).
3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Name: 3-Methyl-4-nitro-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics