N,N’-Dioxide/Gadolinium(III)-Catalyzed Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Pyrazolamides was written by Yao, Qian;Wang, Zhen;Zhang, Yuheng;Liu, Xiaohua;Lin, Lili;Feng, Xiaoming. And the article was included in Journal of Organic Chemistry in 2015.Formula: C5H7ClN2 This article mentions the following:
A highly efficient N,N’-dioxide/Gd(III) complex has been developed for the enantioselective conjugate addition of nitroalkanes to α,β-unsaturated pyrazolamides. Under mild reaction conditions, a series of γ-nitropyrazolamides, e.g., I, were obtained in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 99% ee). What’s more, the optically active products could be easily transformed into γ-nitroesters which were key intermediates for the preparation of paroxetine, pregabalin and boclofen. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Formula: C5H7ClN2).
4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Formula: C5H7ClN2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics